Methoxetamine (MXE)

Date: May 18, 2018

Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class. It is considered an analog of ketamine that also contains structural features of eticyclidine and 3-MeO-PCP, and is thought to be psychoactive. However, to date, no authoritative source can confirm whether it is.

Like ketamine, it is thought to behave as a NMDA receptor antagonist and dopamine reuptake inhibitor, though it has not been formally profiled pharmacologically. Methoxetamine differs from many other dissociative anesthetics of the arylcyclohexylamine class in that it was designed to be available for non-license market distribution.

Methoxetamine is a product of rational drug design: its N-ethyl group was chosen to increase potency, lessening the risk of interstitial cystitis that can result from the accumulation of ketamine-like metabolites in the urinary bladder.


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